Department of Neuroscience
Present PI Affiliations:
George Wilcox, Carolyn Fairbanks
Years of University Contribution: 20
Awards: Patrick J. Manning
Publications:
Fairbanks, CA, Posthumus,
IJ, Kitto, KF, Stone, LS and Wilcox, GL (2000) Moxonidine, a
selective imidazoline/a2 adrenergic receptor agonist, synergizes with
morphine and deltorphin II to inhibit substance P-induced behavior in
mice. Pain 84:13-20.
Fairbanks, CA, Schreiber,
KL, Brewer, KL, Yu, CG, Stone, LS, Kitto, KF, Nguyen, HO, Grocholski,
BM, Shoeman, DW, Kehl, LJ, Regunathan, S, Reis, DJ, Yezierski, RP and
Wilcox, GL (2000) Agmatine reverses pain induced by inflammation, neuropathy,
and spinal cord injury. Proceedings of the National Academy of Sciences
97:19584-10589.
Fairbanks, CA, Stone,
LS, Kitto, KF, Nguyen, HO, Posthumus, IJ and Wilcox, GL (in press)
Alpha2C adrenergic receptors mediate spinal analgesia and adrenergic-opioid
synergy. J. Pharmacol. Exp. Therap.
Giovengo, SL, Kitto,
KF, Kurtz, HJ, Velazquez, RA and Larson, AA (1999) Parenterally
administered kainic acid induces a persistent hyperalgesia in the mouse
and rat. Pain 83:347-58.
Kitto, KF, Haley,
JE and Wilcox, GL (1992) Involvement of nitric oxide in spinally mediated
hyperalgesia in the mouse. Neurosci. Lett. 148:1-5.
Larson, AA and Kitto,
KF (1995) Sensitization to the behavioral effect of kainic acid
in the mouse is mediated by nitric oxide. J. Pharmacol. Exp. Ther.
275:544-550.
Larson, AA and Kitto,
KF (1997) Mutual antagonism between nerve growth factor and substance
P N-terminal activity on nociceptive activity in mice. J. Pharmacol.
Exp. Therap. 282:1345-1350.
Laughlin, TM, Kitto,
KF and Wilcox, GL (1998) Redox manipulation of NMDA receptors in
vivo: alteration of acute pain transmission and dynorphin-induced allodynia.
Pain 80:37-43.
Roerig, S, Lei, S,
Kitto, K, Hylden, JLK and Wilcox, GL (1992) Spinal interactions
between opioid and noradrenergic agonists in mice: Multiplicitivity
involves d and a2 receptors. J. Pharmacol. Exp. Ther. 262:365-374.
Stone, LS, Macmillan,
L, Kitto, KF, Limbird, L and Wilcox, GL (1997) The a2a-adrenergic
receptor subtype mediates spinal analgesia evoked by a2 agonists and
is necessary for spinal adrenergic/opioid synergy. J. Neurosci. 17:7157-7165.
Velazquez, RA, Kitto,
KF and Larson, AA (1997) CP-96,345, which inhibits [3H] substance
P binding, selectively inhibits the behavioral response to intrathecally
administered N-methyl-D-aspartate, but not substance P, in the mouse.
J. Pharmacol. Exp. Therap. 281:1231-1237.
