Department of Pharmaceutics
Present PI Affiliation:
George Wilcox, Carolyn Fairbanks
Years of University Contribution: 12
I joined Dr. Wilcox's
laboratory in June 1994 as part of a high school summer research internship
program and returned the following summer for a second summer research
experience. As it turned out, I remained as a part-time student laboratory
assistant for the duration of my college years. Following graduation, I
participated in some graduate level coursework in the Graduate Program
in Pharmacology. In May 2001, I joined the University of Minnesota College
of Pharmacy as a Professional and Administrative Research Coordinator with
the research program of Dr. Carolyn Fairbanks. I tremendously enjoy being
a part of the scientific community here at the University of Minnesota;
I particularly enjoy attending weekly seminars and journal clubs of the
Depts of Neuroscience, Pharmaceutics and Pharmacology. I look forward
to many more years working with my laboratory team members as well as members
of the Center for Pain Research.
During my time in the
lab, I have acquired knowledge and mastery in a variety of animal and molecular
biology experimental
assays including: intrathecal
injection, interarticular injection, mechanical and thermal sensory assessment,
spinal-nerve ligation surgery, trans-electrical nerve stimulation, antibody
production, immunocytochemistry, and genotyping. In the future I hope to
incorporate more genomics oriented techniques. In addition to my experimental
skills, I am also responsible for administrative tasks including: personnel
training and scheduling, laboratory supply ordering, chemical database,
research subject forms database, selection and optimization of equipment
and methods
for the laboratory. I also contribute to the management of the University
of Minnesota Center for Pain Research.
Publications:
Goracke-Postle CJ, Nguyen HO, Stone LS, Fairbanks CA. (2006) Release of tritiated agmatine from spinal synaptosomes. Neuroreport 17(1):13-7.
King EW, Audette K, Athman GA, Nguyen HO, Sluka KA, Fairbanks CA. (2005) Transcutaneous electrical nerve stimulation activates peripherally located alpha-2A adrenergic receptors. Pain 115(3):364-73.
Nguyen HO, Goracke-Postle CJ, Kaminski LL, Overland AC, Morgan AD, Fairbanks CA. (2003) Neuropharmacokinetic and dynamic studies of agmatine (decarboxylated arginine). Ann N Y Acad Sci. 1009:82-105.
Fairbanks, CA, Stone, LS, Kitto, KF, Nguyen, HO, Posthumus, IJ, Wilcox, GL. (2002) Alpha2C adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy. J. Pharmacol. Exp. Therap. 300(1):282-90.
Fairbanks, CA, Nguyen,
HO, Grocholski, BM, Wilcox, GL. (2000) Moxonidine, a selective
imidazoline-a2-adrenergic receptor agonist, produces spinal synergistic
antihyperalgesia with morphine in nerve-injured mice. Anesthesiol.
93:765-773.
Fairbanks, CA, Schreiber,
KL, Brewer, KL, Yu, CG, Stone, LS, Kitto, KF, Nguyen, HO, Grocholski,
BM, Shoeman, DW, Kehl, LJ, Regunathan, S, Reis, DJ, Yezierski, RP,
Wilcox, GL. (2000) Agmatine reverses pain induced by inflammation, neuropathy,
and spinal cord injury. Proc Natl Acad Sci U S A.
97:19584-10589.
Stone LS, Fairbanks CA, Laughlin TM, Nguyen HO, Bushy TM, Wessendorf MW, Wilcox GL. (1997) Spinal analgesic actions of the new endogenous opioid peptides endomorphin-1 and -2. Neuroreport 8(14):3131-5.
